Clinical Research

Select Clinical Stage to Explore

Demonstrating clinically meaningful reductions in depressive symptoms

SparkRx has been studied in a nationwide, randomized controlled trial (NCT04524598). The results showed clinically meaningful ¹⁻² reductions in depressive symptoms.

Intention-to-Treat Analysis

Participants who received SparkRx (n = 63) showed a clinically meaningful reduction in depression symptoms. At the end of the study, 24% of SparkRx participants had a treatment response and 17% were in remission. The intention-to-treat analysis comparing Spark to Control was not significant.

Per-Protocol Analysis

For participants that consistently engaged with their assigned program (n = 83), SparkRx led to a statistically significant reduction in depression symptoms compared to Control (p = 0.023) and a 21% remission rate compared to a 4% remission rate for Control at the end of treatment. Treatment response rates were 29% and 16%, respectively, for SparkRx and Control.

Learn more about SparkRx

SparkRx is available now under the FDA’s policy to treat psychiatric disorders during COVID-19. Providers interested in offering SparkRx to their patients can visit the SparkRx website to register and view important safety information. Teens and young adults can also visit the website to learn more about how to get access to SparkRx.

Visit the SparkRx website

Grounded in Clinically Validated Treatment

Cognitive-behavioral therapy (CBT) has been shown to be effective in the prevention and treatment of depression in children and adolescents, and is recommended as a first-line treatment for depression by the American Academy of Pediatrics.

Because certain neural systems in the brains of adolescents are still developing, teenagers demonstrate more reward-seeking behaviors than adults and have a greater tendency to engage in harmful and avoidant behaviors during depressive episodes. 

Reinforcing healthy behaviors and social engagement may be particularly helpful for treating depression in adolescents. A focus on psychoeducation and encouraging and reinforcing positive behavior may also be appealing to teenagers who struggle with the corrective approach that supports some traditional therapy models.

Collaborate with Limbix

Interested in partnering for clinical research? Please contact: research@limbix.com

Footnotes
1. Löwe, B., Unützer, J., Callahan, C. M., Perkins, A. J., & Kroenke, K. Monitoring depression treatment outcomes with the patient health questionnaire-9. Med Care, 42, 1194–1201 (2004).

2. Donkin, L., et al. Rethinking the dose-response relationship between usage and outcome in an online intervention for depression: randomized controlled trial. J Med Internet Res, 15, e231. 10.2196/jmir.2771 (2013).

Additional References
McCauley, E., Gudmundsen, G., Schloredt, K., Martell, C., Rhew, I., Hubley, S., & Dimidjian, S. (2015). The Adolescent Behavioral Activation Program: Adapting Behavioral Activation as a Treatment for Depression in Adolescence. Journal of Clinical Child & Adolescent Psychology, 45(3), 291–304. https://doi.org/10.1080/15374416.2014.979933

McCauley, E., Schloredt, K. A., Gudmundsen, G. R., Martell, C. R., & Dimidjian, S. (2016). Behavioral Activation with Adolescents: A Clinician’s Guide (Illustrated ed.). The Guilford Press.

Pass, L., Hodgson, E., Whitney, H., & Reynolds, S. (2018). Brief Behavioral Activation Treatment for Depressed Adolescents Delivered by Nonspecialist Clinicians: A Case Illustration. Cognitive and Behavioral Practice, 25(2), 208–224. https://doi.org/10.1016/j.cbpra.2017.05.003

Pass, L., Lejuez, C. W., & Reynolds, S. (2017). Brief Behavioural Activation (Brief BA) for Adolescent Depression: A Pilot Study. Behavioural and Cognitive Psychotherapy, 46(2), 182–194. https://doi.org/10.1017/s1352465817000443

FCOI Policy